A New Indole Derivative, LWX-473, Overcomes Glucocorticoid Resistance in Jurkat Cells by Activating Mediators of Apoptosis
Background: Glucocorticoids (GCs) are commonly used as the primary chemotherapy for lymphoid malignancies, including acute lymphoblastic leukemia (ALL).However, the development of GC resistance limits their prolonged use.Methods: In this study, we investigated the potential of a newly synthesized indole derivative called LWX-473, BACKPACKS in combi